Utmatningsformat. html, text, asciidoc, rtf. html. Skapa Stäng. Pleiotropic effects of inactivating a carboxyl-terminal protease, CtpA, in Borrelia burgdorferi 


2021-04-10 · The pleiotropic effects of statins may be due to the fact that they are antibiotics. This intriguing theory is discussed including statins effects CRP and sepsis and the possible association with

16. Robinson JG, Smith  International conference. Abbott, J. K. & Tazzyman, S. J. (2016) Pleiotropic effects on investment permit the maintenance of polymorphic sexually antagonistic  av N Ausmees · 2007 · Citerat av 59 — Deletion of smeA-sffA gave rise to pleiotropic effects on spore maturation, and influenced the segregation of chromosomes and placement of septa during  14 nov. 2017 — Pleiotropic effects of statin on the cardiovascular system. Circ Res. SS, Blumenthal RS. Non-cardiovascular effects associated with statins.

Pleiotropic effects

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Definition of pleiotropic. : producing more than one effect especially : having multiple phenotypic expressions a pleiotropic gene. An antagonistically pleiotropic gene can be selected for if it has beneficial effects in early life while having its negative effects in later life because genes tend to have larger impacts on fitness in an organism's prime than in their old age. An example of this is testosterone levels in male humans. Recent experimental evidence supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque vulnerability). Pleiotropic effects of IL-8 on leukocytes have also been delineated in part by the use of antisense approaches.

Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: An expert panel position paper. Artikel i 

2018-12-14 MCP also reduces fibrosis to the kidney, liver, and adipose tissue. Other benefits of MCP include detoxification and improved immune function. This review summarizes the pleiotropic effects of MCP. Keywords: cancer; cardiovascular; fibrosis; galectin; inflammation; pectasol. 2019-07-11 The pleiotropic effects of IGF-1 and insulin on cellular metabolism, mitogenesis, apoptosis, and survival and cytodifferentiation are mediated by a complex network of intracellular signaling pathways [1].

Pleiotropic effects

2014-04-08 · 3. Pleiotropic effects of statins. However, the overall clinical benefits observed with statin therapy appear to be greater than what might be expected from changes in lipid profile alone, suggesting that the beneficial effects of statins may extend beyond their effects on serum cholesterol levels.

2013-07-01 · Pleiotropic effects of rosuvastatin on the liver ultrastructure. Mice were fed the standard chow (SC) or a high-fat diet (HF) for 15 weeks, followed by five weeks of rosuvastatin treatment at doses of 10 mg/kg/day (HF-R10), 20 mg/kg/day (HF-R20), or 40 mg/kg/day (HF-R40). Numerical density of mitochondria assessed by stereology. pleiotropic effects of pitavastatin. Screening removed all conference abstracts, review articles or correspondence (editorials and letters) and articles not relevant to the pleiotropic effects of pitavastatin, yielding a total of 134 relevant articles for further assessment. Relevant papers published after December 2010 were also included as As a result, the pleiotropic effects of m.4295A>G mutation on tRNA Ile metabolism including the processing of tRNA precursors, stability and aminoacylation of tRNA Ile contributed to marked reductions in the steady-state level of tRNA Ile, in contrast with mild reductions in tRNA Asp and tRNA Met observed in the cell lines bearing the m.7551A>G and m.4435A>G mutations (31, 32). Pleiotropic preventive effects of dietary polyphenols in cardiovascular diseases.

Pleiotropic effects

The Pleiotropic Effects of a Drug . In defense of the care providers in such settings, they feel tremendous pressure from the patients who come to see them that "they want what they want." Thus, it is not surprising that mutations in genes which function in melanocyte development or melanogenesis frequently cause pleiotropic effects involving sight, hearing and neurologic functioning. Many pleiotropic effects recently studied in mice have come from investigating mutagenesis screens and knockout mutations. Pleiotropic effects of_statins 1. PLEIOTROPIC EFFECTS OF STATINS Dr.RENJU.S.RAVI MD 2. Cholesterol Cholesterol is an essential component of cell membranes and is the immediate precursor of steroid hormones and bile acids.

Statin pleiotropy is an important concept. In cell culture and animal studies, these effects alter the expression of endothelial nitric oxide synthase, the stability of atherosclerotic plaques, the production of proinflammatory cytokines and reactive oxygen species, the reactivity of platelets, and the development of cardiac hypertrophy and fibrosis. Pleiotropic effects mediated by inhibition of isoprenoids correlate with the inhibition of cholesterol biosynthesis and are difficult to quantitate.

The multiple phenotypic effect of a single gene is called pleiotropism.
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gut, bone, pararthyroids, muscle and brain. Alfacalcidol is superior to plain vitamin D (​cholecalciferol)  From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols och book to systematically exhibit the powerful pleiotropic pharmacological effects on​  Effects of a Mediterranean-style diet Effect of potentially modifiable risk factors associated (pleiotropic) effects of statins in the management of acute coronary​  8 maj 2013 — However, the link between glycogen depletion and impaired muscle function during fatigue is not well understood and a direct cause‐and‐effect  av AA Pioszak · 2008 · Citerat av 258 — The pleiotropic effects of PTH are mediated primarily through the binding and activation of the PTH receptor (PTH1R), which is highly  10 juni 2016 — Effect of potentially modifiable risk factors associated with myocardial Pleiotropic effects of statins: benefit beyond cholesterol reduction? 3076 dagar, Accelerated and enhanced effect of CCR5-transduced bone marrow 3121 dagar, Pleiotropic effects of miR-183~96~182 converge to regulate cell  för 5 dagar sedan — LOY-associated transcriptional effect (LATE) was observed in ~ 500 of leukocytes, suggesting that LOY might have pleiotropic effects. Furthermore, the combined effect of these variants showed generalizability autoimmune-related and other pleiotropic effects of lung function-associated  Siegel, G et al, Pleiotropic effects of garlic, Wien Med Wochenschr. 1999;149(8-10):217-24.