Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania. Biological Psychiatry, 50, 418-424. References 32 healthy controls and 35 bipolar patients (23 mixed, 11 manic, and 1 undefined) were recruited from ongoing pharmacokinetic studies in which they were enrolled independent of the present sensory gating protocol

Studies of PPI as an operational measure of sensorimotor gating were originally intended to test the general theory that failures of inhibitory filtering mechanisms can lead to sensory overload and consequent cognitive fragmentation in schizophrenia (Geyer and Braff, 1987; Braff and Geyer, 1990). Sensory gating and sensorimotor gating in psychiatric disorders sharing attention deficits Holstein, Dominique H Abstract: Functional gating is an important function of the brain, preventing it from a sensory overload by filtering out irrelevant stimuli. A deficit in gating is characterized by a general reduction of the ability From the Department of Psychiatry, University of California, San Diego, La Jolla. • Human and animal model studies of sensorimotor gating allow us to understand the functional significance of attentional abnormalities and monoaminergic alterations in patients with schizophrenic disorders. Clinically, schizophrenic patients report oversensitivity to sensory stimulation that theoretically correlates with stimulus overload and leads to cognitive fragmentation.

Sensorimotor gating disorders

This is consistent with a 'double dose' of deficit explanation amongst those with both diagnoses, explained at least in part by presence of antisocial personality traits and childhood psychosocial deprivation. Sensorimotor gating, defined as the state-dependent regulation of transmission of sensory information to a motor system, is coming of age. It has been known for decades that sensory information does not have unfettered access to its targets in the central nervous system (CNS), as has the fact that sensorimotor gating often occurs via presynaptic inhibition of the activated sensory neuron(s) . Sensorimotor Gating Deficits in Psychiatric disorders. Studies of PPI as an operational measure of sensorimotor gating were originally intended to test the general theory that failures of inhibitory filtering mechanisms can lead to sensory overload and consequent cognitive fragmentation in schizophrenia (Geyer and Braff, 1987; Braff and Geyer, 1990).

Animal Models of Maladaptive Traits: Disorders in Sensorimotor Gating and Attentional Quantifiable Responses as Possible Endophenotypes. Fernando Alonso. Juan Vargas. Fernando Alonso.

Sensory gating and sensorimotor gating in patients suffering from attention-deficit/hyperactivity disorder (ADHD). 9. 1 Jun 2009 Abstract.

2018-05-17

9. 1 Jun 2009 Abstract.

17 May 2018 Startle habituation, sensory, and sensorimotor gating in trauma-affected refugees with posttraumatic stress disorder - Volume 49 Issue 4. 30 May 2018 Sensorimotor gating is impaired in male patients with bipolar disorder (BP) and depression, according to results published in Psychiatry. Request PDF | Sensory gating and sensorimotor gating in psychiatric disorders sharing attention deficits | Functional gating is an important function of the brain, Background: Deficits in sensorimotor gating as assessed by prepulse inhibition ( PPI) and habituation of the human startle response have been noted in 27 Oct 2010 Prepulse inhibition (PPI) of the acoustic startle reflex is an operational measure of sensorimotor gating that is amenable to cross-species posttraumatic stress disorder (PTSD). 7. 1.2.3.
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Sensorimotor gating in manic and mixed episode bipolar disorder. Carroll CA(1), Vohs JL, O'donnell BF, Shekhar A, Hetrick WP. Author information: (1)Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA. Prepulse Inhibition (PPI) of startle is an operational measure of the pre-attentive filtering process known as sensorimotor gating. Originally identified in patients with schizophrenia, PPI deficits have been observed in multiple but not all psychiatric disorders. 2012-01-04 · Sensorimotor gating refers to the process by which a neural system screens or ‘gates’ extraneous external (sensory) and internal (cognitive, motor) information from higher order processing and Startle habituation, sensory, and sensorimotor gating in trauma-affected refugees with posttraumatic stress disorder.

Juan Vargas. Fernando Alonso. An important objective in this investigation is to clarify whether sensorimotor gating deficits are also present in other dopaminergic dysregulated disorders with inhibitory impairments.
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Background: Prepulse inhibition (PPI) is an operational measure of sensorimotor gating and is impaired in a family of neuropsychiatric disorders characterized by abnormalities of inhibitory function. Adults with autistic disorder (AD) exhibit clinical features of inhibitory deficits, such as restrictive and repetitive behaviors, that may be explained by deficits in sensorimotor gating.

One measure that is often used to evaluate the translational relevance of these models to human neuropsychiatric disease is prepulse inhibition of startle (PPI), an operational measure of sensorimotor gating. Deficient PPI characterizes several neuropsychiatric disorders but has been most extensively studied in schizophrenia. 2001-09-15 · The fact that sensorimotor gating disturbances have been found across a number of neuropsychiatric disorders associated with CSPT disturbances but with distinct phenomenologic characteristics may be a result of disturbances at different elements along the CSPT circuitry (Swerdlow and Koob 1990). Sensorimotor Gating in Depressed and Euthymic Patients with Bipolar Disorder: Analysis on Prepulse Inhibition of Acoustic Startle Response Stratified by Gender and State Junko Matsuo, Miho Ota, Shinsuke Hidese, Toshiya Teraishi, Hiroaki Hori, Ikki Ishida, Moeko Hiraishi and Hiroshi Kunugi* Thus, sensorimotor and sensory gating measures can be used as informative and independent neurophysiological markers for studies investigating neuropsychiatric disorders and may well constitute separable endophenotypes.